Nanoscale Particles for Lung Delivery of siRNA

Multicompartmental particles for combined imaging and siRNA delivery.

The controlled delivery of genetic material, such as genes, plasmids, or siRNA, holds great promise for the therapy of a number of debilitating diseases. [ 1–3 ] While the fundamental concept of permanent or temporary genetic manipulation has been widely embraced by the scientifi c community, severe concerns remain about the safe and effi cient transfer of the genetic material into human cells,...

Cell-penetrating-peptide-mediated siRNA lung delivery.

The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human disease. However, the major obstacle to its use has been the difficulty in delivering these large anionic molecules in vivo. A potential approach to solving this problem is the chemical conjugation of siRNA to the cationic CPPs (cell-penet...

NANOPARTICLE-MEDIATED siRNA DELIVERY FOR LUNG CANCER TREATMENT

Dendrimers for siRNA Delivery

Since the discovery of the "starburst polymer", later renamed as dendrimer, this class of polymers has gained considerable attention for numerous biomedical applications, due mainly to the unique characteristics of this macromolecule, including its monodispersity, uniformity, and the presence of numerous functionalizable terminal groups. In recent years, dendrimers have been studied extensively...

Nanoscale Metal Particles as Nanocarriers in Targeted Drug Delivery System

Submit Manuscript | http://medcraveonline.com release process [1-8]. The comfort factors in using nanoscale metal particles are attained from their capability to increase the aqueous solubility of hydrophobic drugs compound, enhanced the circulation time of drugs in the blood, and repress or eliminate fast renal drugs excretion. Nevertheless, the clinical success of these agents is crucially re...